Title:Interaction of folic acid and some matrix metalloproteinase (MMP) inhibitor folate-γ-hydroxamate derivatives with Zn(II) and human serum albumin
DOI:10.1016/j.jinorgbio.2010.12.008
ligand name:folate-γ-phenylalanine
ligand smiles:NC1=NC2=NC=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)NC(CC3=CC=CC=C3)C(O)=O)C(O)=O)N=C2C(=O)N1
key residue(hbond):
key residue(hydrophobic):
PDB ID:
Binding Area:

#Binding and thermodynamic parameters#
parameter;295;
pH;
T;298;
KSV;10^5.4;
kq;
n;
K;
Ka;
Kb;10^5.74;
ΔH;
ΔS;
ΔG;
Kd;1.8;


#ITC#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Cp;
Kd;


#UV-vis absorption spectroscopy#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#other_method#method;
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#Kinetic Parameters Describing Michaelis–Menten Constant#
HSA/Ligand;RA (%);Vmax;Km;kcat;kcat/Km;



#FRET from Steady State Measurements#
parameter;
T;
pH;
T;
J;
E;
R0;
r;
EFRET;
F0;
F;


#Changes in the ASA(Å2) Values of the Interacting Residues of HSA and ligand Complex
residues;ASA(Å2) of HSA;ASA(Å2)of com;ΔASA(Å2)





