Title:Spectroscopic approach of the interaction study of amphiphilic drugs with the serum albumins
DOI:10.1016/j.colsurfb.2011.06.007
ligand name:PMT
ligand smiles: CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl  
key residue(hbond):
key residue(hydrophobic):
PDB ID:
Binding Area:

#Binding and thermodynamic parameters#
parameter;280nm;290nm;
pH;
T;310;310;
KSV;2.71*10^4;2.99*10^4;
kq;2.71*10^12;2.99*10^12;
n;1.051;0.967；
K;5.16*10^4;1.95*10^4;
Ka;
Kb;
ΔH;
ΔS;
ΔG;-27.02;-24.60;
Kd;


#ITC#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Cp;
Kd;


#UV-vis absorption spectroscopy#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#other_method#
method;
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#Kinetic Parameters Describing Michaelis–Menten Constant#
HSA/Ligand;RA (%);Vmax;Km;kcat;kcat/Km;




#FRET from Steady State Measurements#
parameter;
pH;
T;
J;
E;
R0;
r;
EFRET;
F0;
F;


#Changes in the ASA(Å2) Values of the Interacting Residues of HSA and ligand Complex
residues;ASA(Å2) of HSA;ASA(Å2)of com;ΔASA(Å2)





