Title:The effect of chrysin binding on the conformational dynamics and unfolding pathway of human serum albumin
DOI:10.1016/j.saa.2024.124332
ligand name:chrysin
ligand smiles:C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
key residue(hbond):
key residue(hydrophobic):
PDB ID:
Binding Area:subdomain II


#Binding and thermodynamic parameters#
parameter;
pH;
T;298;
KSV;4.0826*E5;
kq;5.96*E13;
n;0.96;
K;
Ka;2.70*E5;
Kb;
ΔH;
ΔS;
ΔG;-30.5432;
Kd;


#ITC#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Cp;
Kd;


#UV-vis absorption spectroscopy#
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#other_method#
method;
parameter;
pH;
T;
n;
K;
Ka;
Kb;
ΔH;
ΔS;
ΔG;
Kd;


#Kinetic Parameters Describing Michaelis–Menten Constant#
HSA/Ligand;RA (%);Vmax;Km;kcat;kcat/Km;



#FRET from Steady State Measurements#
parameter;
pH;
T;
J;
E;
R0;
r;
EFRET;
F0;
F;

#Changes in the ASA(Å2) Values of the Interacting Residues of HSA and ligand Complex
residues;ASA(Å2) of HSA;ASA(Å2)of com;ΔASA(Å2)





